The EWAS Catalog: a database of epigenome-wide association studies

Epigenome-wide association studies (EWAS) seek to quantify associations between traits/exposures and DNA methylation measured at thousands or millions of CpG sites across the genome. In recent years, increase in availability measures population-based cohorts case-control has resulted a dramatic expansion number EWAS being performed published. To make this rich source results more accessible, we have manually curated database CpG-trait (with p<1x10-4) from published EWAS, each assaying over 100,000 CpGs least 100 individuals. From January 7, 2022, The Catalog contained 1,737,746 2,686 EWAS. This includes 1,345,398 342 peer-reviewed publications. addition, it also contains summary statistics for 392,348 427 on data Avon Longitudinal Study Parents Children (ALSPAC) Gene Expression Omnibus (GEO). is accompanied by web-based tool R package, giving researchers opportunity query quickly easily, gain insight into molecular underpinnings disease as well impact traits exposures methylome. extraction team continue update monthly encourage any authors upload their our website. Details how can be found here: http://www.ewascatalog.org/upload. available ns4:href="http://www.ewascatalog.org">http://www.ewascatalog.org.